Semaglutide Reconstitution Calculator
A long-acting GLP-1 receptor agonist. FDA-approved for type 2 diabetes (Ozempic) and chronic weight management (Wegovy).
Informational only. Not medical advice. Consult a licensed healthcare provider before starting, changing, or stopping any protocol.
Semaglutide
About Semaglutide
FDA-approved prescription drug. Available via licensed prescriber.
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. FDA-approved as Ozempic (2017) for type 2 diabetes and as Wegovy (2021) for chronic weight management in adults with obesity or overweight with comorbidities. An oral formulation, Rybelsus, is also available. Extensive phase-3 trial data — the STEP and SUSTAIN programs — underpins both approvals.
With a half-life of approximately 7 days (168 hours), semaglutide is dosed once weekly subcutaneously. Typical titration starts at 0.25 mg/week and escalates every 4 weeks to a maintenance dose of 1.0–2.4 mg/week, depending on indication and response. Compounded semaglutide (from licensed 503A/503B pharmacies) has been widely available in the U.S. market during 2023–2026 amid branded-product shortages, though the FDA's 2024 declaration of resolved shortage has evolved the regulatory landscape.
This calculator handles compounded semaglutide reconstitution: a user enters the mg of powder in their vial, the volume of bacteriostatic water added, and their target weekly dose in mcg — and gets the exact number of insulin-syringe units to draw.
Brand names: Ozempic, Wegovy, Rybelsus
Frequently asked questions
- What's the standard titration schedule?
- FDA labeling for Wegovy specifies: 0.25 mg/week for 4 weeks, then 0.5 mg for 4 weeks, then 1.0 mg for 4 weeks, then 1.7 mg for 4 weeks, then 2.4 mg as maintenance. Titration is clinician-directed; apply the "GLP-1 Onboarding" template to pre-populate this schedule in your log.
- How do I convert mg to mcg?
- 1 mg = 1,000 mcg. So a 0.25 mg dose = 250 mcg. Enter 250 in the "target dose" field (mcg is the working unit for the calculator).
- What's a typical compounded vial strength?
- Compounded semaglutide commonly ships as 2 mg, 4 mg, or 8 mg vials. Reconstitution volumes vary — check your pharmacy's instructions. The calculator accepts any vial-strength and BAC-water combination.
Sources
- Wilding JPH, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." NEJM. 2021. PMID: 33567185
- Davies M, et al. "Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2)." Lancet. 2021. PMID: 33667417
- Wegovy (semaglutide) FDA Prescribing Information. Novo Nordisk. 2021.
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