MOTS-c Reconstitution Calculator

A 16-amino-acid peptide encoded by the mitochondrial genome. Preclinical research explores roles in metabolism and exercise response.

Informational only. Not medical advice. Consult a licensed healthcare provider before starting, changing, or stopping any protocol.

Reconstitution calculator

MOTS-c

Syringe type
Your dose
Draw 200 units
That's 2 mL of your reconstituted solution · Concentration 5,000 mcg/mL
This vial gives you 1 doses at 10,000 mcg
0102030405060708090100200 units
Exceeds one full syringe — multiple draws needed. Consider a larger syringe or less concentrated solution.
Math is open source · Educational use only · Not medical advice

About MOTS-c

Not FDA-approved. Sold as a research chemical. Regulatory status varies by jurisdiction. Users are responsible for legal compliance.

MOTS-c is a peptide encoded by the mitochondrial genome rather than the nuclear genome — making it one of a small class of mitochondrial-derived peptides (MDPs). It was discovered in 2015 at USC (Lee et al, Cell Metabolism). Preclinical research has explored its roles in insulin sensitivity, metabolic regulation, exercise-induced physical capacity, and age-dependent muscle homeostasis.

Half-life is approximately 24 hours. Users tracking MOTS-c in this app typically log 5,000–15,000 mcg per injection, three times weekly. MOTS-c is NOT FDA-approved and is classified as a research chemical.

Frequently asked questions

What makes MOTS-c special?
It's one of the few known peptides encoded in the mitochondrial genome. This distinguishes it from nuclear-encoded peptides and suggests a role in mitochondria-nucleus communication that has been actively researched since its 2015 discovery.
How is MOTS-c related to exercise?
Preclinical studies (Reynolds et al, 2021) reported MOTS-c as an exercise-induced mitochondrial regulator relevant to age-related physical decline. This has attracted research interest around "exercise mimetic" applications — though no clinical approval exists.
Is MOTS-c commonly stacked with NAD+?
Yes — the "Longevity Foundations" stack template in the app pairs MOTS-c with NAD+ because both target mitochondrial function via distinct mechanisms.

Sources

  1. Lee C, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell Metab. 2015. PMID: 25738459
  2. Reynolds JC, et al. "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis." Nat Commun. 2021. PMID: 33707442

Related calculators

The app runs every compound.

This page runs one. My Pep Calc runs your whole stack — reconstitution math feeds your dose log, which feeds your site rotation map and the half-life chart. First 500 founders get Lifetime Pro for $149.

See the Founders offer →